Nanoagent functionalization aiming at tumor targeting and biocompatibility
Host Institute: Chematech & University of Bourgogne, Dijon
Supervisor: Dr. Frederic Boschetti, CEO, Chematech & Dr. Franck Denat, Director, Institute of Molecular Chemistry, University of Bourgogne, Dijon, France
Nanotechnology has started witnessing some applications in the area of therapeutics and diagnostics particularly for the management of cancer therapy.
This potential has been further augmented through the vast explorations at the interface of materials science and biology to develop smart multifunctional systems.
My research project at Chematech, Dijon and University of Bourgogne, Dijon steers in similar direction.
The objective of the project is to develop novel and facile strategies to synthesize nanoparticles for the imaging and therapy of cancer. These nanoparticles will be thoroughly characterized for its physico-chemical properties through a gamut of chromatographic, spectroscopic and biophysical techniques. These nano dimensional particles will be optimized for the efficient labelling with a suitable contrast/radio agents for the applications in imaging/therapy.
Furthermore, the project also aims to conjugate these nanoparticles with suitable bio recognized ligands so as to selectively dart the cancerous tissue. Such an approach demands substantial manipulation and investigations at the chemical/biophysical level.
The appropriately optimized systems will be rigorously evaluated in suitable biological rodent models to understand the biodistribution, pharmacokinetics and overall applicability of such tools in cancer imaging and therapy.
The aforementioned activities will be carried out through the intense collaboration with the ITN-ARGENT project partners across Europe. The long term goal of the project will be to develop robust nanosystems which are well positioned to make a translation from bench to the bed.
2010: Master of Science (Pharm.) in Pharmaceutics, National Institute of Pharmaceutical Education and Research, Mohali
2008: Bachelor of Pharmaceutical Sciences, Institute of Chemical Technology (formerly UDCT), Mumbai University
2011-2014: Scientist, Formulations & Analytical, Research & Development, Biocon Ltd, Electronics City, Bangalore-560100
July 2010 - Dec2010: Technical Trainee, Technology Transfer Group, Formulation Technology Operations, Dr.Reddy’s Laboratories, Bachupally, Hyderabad, Andhra Pradesh-500090
1. Ramanpreet Singh, Manasmita Das, Vivek S. Thakare, Sanyog Jain. Functionalization density dependant cell uptake and cytotoxicity of carboxylated carbon nanotubes in a murine macrophage cell line. Chemical Research in Toxicology 25(10), 2012: 2127-37. Impact Factor –4.148.
2. Sanyog Jain, Vivek S. Thakare, Manasmita Das, C. Godugu, Amit Jain et.al,. Toxicity of multiwalled carbon nanotubes with end-defects critically depends on their functionalization density. Chemical Research in Toxicology 24(11), 2011: 2028-2039. American Chemical Society, Impact Factor – 4.148
3. Vivek S. Thakare, Mansmita Das, Amit K Jain, Swapnil Patil, Sanyog Jain, Carbon Nanotubes in cancer Theragnosis, Nanomedicine (Lond.) 5(8), 2010: 1277-1301. Future Medicine Ltd, Impact Factor – 5.92.